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Real members of myITPteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

I was on Alvaiz for 6 months seeing improvements from being at 15 to finally getting into the triple digits of low 100's. Then my employer change insurance carriers and the insurance company told me I had to go on promacta. Platelets dropped, start over on steroids. Now on Cellcept, not working. It has been 8 months seeing no improvement. I have dropped to 60. Doctor asked to change to Doptelet and the insurance denied. Insurance company stated I had to try 2 new medicines first before… read more

September 10
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A myITPteam Member

When insurance forced us on Promacta and it was not working, doctor asked if we could switch to Doptelet. Insurance carrier denied request stating only can prescribe if platelets are under 30.

4 days ago
A myITPteam Member

That’s so strange since I heard Doptelet was viewed now as the go to for most hematologist, even before Promacta because it doesn’t have the dietary restrictions. We are fighting an insurance battle right now, but with a more obscure medicine (Deratumumab). I totally understand your frustration and hope you find ways to get the meds you need!

5 days ago
myITPteam

That frustration is completely valid — and unfortunately, you're not alone in this experience. What you're describing is called step therapy (sometimes called "fail first"), where insurance companies require patients to try cheaper or preferred medications before approving the one your doctor actually wants to prescribe.

Show Full Answer

That frustration is completely valid — and unfortunately, you're not alone in this experience. What you're describing is called step therapy (sometimes called "fail first"), where insurance companies require patients to try cheaper or preferred medications before approving the one your doctor actually wants to prescribe.

The painful irony is that you already found something that worked, and now you're being forced to start over. Here are some steps worth exploring with your specialist:

- Prior Authorization Appeal — Your doctor can formally appeal the denial, especially with documented evidence that Alvarez worked and the alternatives caused your platelets to drop
- Step Therapy Exception — Many states have laws protecting patients from step therapy when a medication has already proven effective. Ask your doctor's office if your state has these protections
- Letter of Medical Necessity — Your specialist can write a detailed letter explaining why returning to what worked is medically necessary
- Patient Assistance Programs — The drug manufacturer may offer support programs if coverage remains denied

Your specialist's clinical judgment absolutely matters here. The key is building a documented paper trail showing the harm caused by switching away from what was working.

September 10

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